Neuromuscular transmission in myasthenic single motor units.
نویسندگان
چکیده
منابع مشابه
Neuromuscular transmission in myasthenic single motor units.
In patients with myasthenia gravis neuromuscular transmission has been tested in individual hypothenar and thenar motor units using trains of near threshold electrical stimuli delivered to the motor nerve. The most important observations included: (1) the proportion of motor units with pathological decrements varied from 0 to 90%, (2) the decrements in surface voltage were frequently much more ...
متن کاملAxonal refractory period of single short toe extensor motor units in neuropathies and neuromuscular diseases.
Electromyographic recordings were carried out on 36 patients with neuropathies and neuromuscular disorders with a selectivity permitting identification of single motor unit potentials during maximal voluntary effort and after supramaximal nerve stimulation. The axonal conduction velocity and refractory period of 117 motor units were determined and the findings were compared to those in previous...
متن کاملCalpain activation impairs neuromuscular transmission in a mouse model of the slow-channel myasthenic syndrome.
The slow-channel myasthenic syndrome (SCS) is a hereditary disorder of the acetylcholine receptor (AChR) of the neuromuscular junction (NMJ) that leads to prolonged AChR channel opening, Ca(2+) overload, and degeneration of the NMJ. We used an SCS transgenic mouse model to investigate the role of the calcium-activated protease calpain in the pathogenesis of synaptic dysfunction in SCS. Cleavage...
متن کاملDirectional tuning of single motor units.
The directional activity of whole muscles has been shown to be broadly and often multimodally tuned, raising the question of how this tuning is subserved at the level of single motor units (SMUs). Previously defined rules of SMU activation would predict that units of the same muscle (or at least of the same neuromuscular compartment) are activated homogeneously with activity peaks in the same "...
متن کاملCongenital Myasthenic Syndromes or Inherited Disorders of Neuromuscular Transmission: Recent Discoveries and Open Questions
Congenital myasthenic syndromes (CMS) form a heterogeneous group of rare diseases characterized by fatigable muscle weakness. They are genetically-inherited and caused by defective synaptic transmission at the cholinergic neuromuscular junction (NMJ). The number of genes known to cause CMS when mutated is currently 30, and the relationship between fatigable muscle weakness and defective functio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1978
ISSN: 0022-3050
DOI: 10.1136/jnnp.41.3.205